VACCINE COMPOSITION COMPRISING LIPOOLIGOSACCHARIDE WITH REDUCED PHASE VARIABILITY

• Main Authors: WEYNANTS, VINCENT, POOLMAN, JAN, BIEMANS, RALPH, DENOEL, PHILIPPE, JENNINGS, MICHAEL, PAUL, FERON, CHRISTIANE, GORAJ, KARINE
• Format: Patent
• Language: English; French
• Published: 22.04.2004
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are less phase variable in terms of their LOS immunotype, and from which novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines can be derived. L'invention concerne le domaine des compositions de vaccins à base de Neisseria, leur production et leur utilisation en médecine. L'invention concerne plus particulièrement des procédés de production de nouvelles souches de méningocoques mises au point par génie génétique à l'aide d'un immunotype de lipooligosaccharide de méningocoque (LOS) à variabilité de phase réduite, et à partir desquelles une nouvelle sous-unité LOS ou des vaccins à base de vésicule de membrane extérieure (ou bleb) de méningocoque peuvent être dérivés.