BICYCLIC UNSATURATED TERTIARY AMINE COMPOUND

A bicyclic unsaturated tertiary amine compound which can inhibit the production of inflammatory cytokine. It is a compound represented by the following general formula (I), pharmacologically acceptable salt thereof, pharmacologically acceptable ester thereof, or pharmacologically acceptable other de...

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Main Authors NAKAO, AKIRA, AOKI, KAZUMASA, NAGASAKI, TAKAYOSHI, KIMURA, TOMIO, OHKAWA, NOBUYUKI
Format Patent
LanguageEnglish
French
Japanese
Published 29.01.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A bicyclic unsaturated tertiary amine compound which can inhibit the production of inflammatory cytokine. It is a compound represented by the following general formula (I), pharmacologically acceptable salt thereof, pharmacologically acceptable ester thereof, or pharmacologically acceptable other derivative thereof: (I) wherein A represents pyrrole or pyrazole; R represents optionally substituted aryl or heteroaryl; R represents optionally substituted heteroaryl; and R represents indolizine. L'invention concerne un composé amine tertiaire bicyclique insaturé pouvant inhiber la production de cytokine inflammatoire. Elle concerne un sel, un ester ou un dérivé pharmacologiquement acceptable dudit composé. Ce composé est représenté par la formule générale (I), dans laquelle A est pyrrole ou pyrazole; R est aryle éventuellement substitué ou hétéroaryle; R est hétéroaryle éventuellement substitué; et R est indolizine.
Bibliography:Application Number: WO2003JP09110