PROCESS FOR THE PURIFICATION OF INTERLEUKIN-4 AND ITS MUTEINS

This invention relates generally to a method for purifying Interleukin-4 or related variants from an Escherichia coli culture medium, where Interleukin-4 and its derivatives are expressed as insoluble protein aggregates, so-called inclusion bodies. L'invention concerne d'une manière généra...

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Bibliographic Details
Main Authors PETERS, JOERG, DELLWEG, HANS-GEORG, MINUTH, TORSTEN
Format Patent
LanguageEnglish
French
Published 22.01.2004
Edition7
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:This invention relates generally to a method for purifying Interleukin-4 or related variants from an Escherichia coli culture medium, where Interleukin-4 and its derivatives are expressed as insoluble protein aggregates, so-called inclusion bodies. L'invention concerne d'une manière générale un procédé permettant de purifier l'interleukine-4 ou des variants connexes d'un milieu de culture d'Escherichia coli, l'interleukine-4 et ses dérivés étant exprimés comme agrégats de protéines insolubles, appelés corps d'inclusion.
Bibliography:Application Number: WO2003EP07022