MULTIMERISED GROWTH HORMONE FUSION PROTEINS

The present invention relates to multimerised growth hormone polypeptides wherein growth hormone is fused with a multimerisation domain, such as a tetranectin trimerising structural element. Thereby there is provided growth hormone multimers, e.g. growth hormone dimers and growth hormone trimers, wi...

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Bibliographic Details
Main Author HOLTET, THOR, LAS
Format Patent
LanguageEnglish
French
Published 15.01.2004
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to multimerised growth hormone polypeptides wherein growth hormone is fused with a multimerisation domain, such as a tetranectin trimerising structural element. Thereby there is provided growth hormone multimers, e.g. growth hormone dimers and growth hormone trimers, with increased biological activity. La présente invention concerne des polypeptides de l'hormone de croissance multimérisée, l'hormone de croissance étant soudée à un domaine de multimérisation, tel qu'un élément structural trimérisant la tétranectine. Ainsi, on obtient des multimères d'hormone de croissance, p.ex. des dimères d'hormone de croissance et des trimères d'hormone de croissance, ayant une activité biologique accrue.
Bibliography:Application Number: WO2003DK00428