ASYMETRIC SYNTHESIS OF AMINO-PYRROLIDINONES

A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below from appropriate pyrrolidinones is described. [Insert Chemical Formula] These compounds are useful as intermediates for MMP and TACE inhibitors. L'invention concerne un nouveau procédé de synthèse asy...

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Main Authors SAVAGE, SCOTT, A, YATES, MATTHEW, MAGNUS, NICHOLAS, A, WALTERMIRE, ROBERT, E, CAMPAGNA, SILVIO, CONFALONE, PASQUALE, N, MELONI, DAVID, J
Format Patent
LanguageEnglish
French
Published 18.12.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below from appropriate pyrrolidinones is described. [Insert Chemical Formula] These compounds are useful as intermediates for MMP and TACE inhibitors. L'invention concerne un nouveau procédé de synthèse asymétrique d'un amino-pyrrolidinone du type illustré ci-dessous à partir de pyrrolidinones appropriés. Ces composés sont utilisés comme intermédiaires pour les inhibiteurs MMP et TACE.
Bibliography:Application Number: WO2003US07969