1ß-METHYLCARBAPENEM DERIVATIVE FOR ORAL ADMINISTRATION

• Main Authors: ASHIDA, YUKA, KOBAYASHI, YOSHIYUKI, KOJIMA, KATSUHIKO, UCHIDA, TAKUYA
• Format: Patent
• Language: English; French; Japanese
• Published: 20.11.2003
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A compound represented by the general formula (I) [wherein R and R each independently represents hydrogen or C1-6 alkyl, R represents C1-15 alkyl, C3-7 cycloalkyl, or C6-10 aryl, n is 1, 2, or 3 X represents sulfur or oxygen, R , R , and R each independently represents hydrogen, C1-6 alkyl, hydroxy(C1-6 alkyl), C3-6 cycloalkyl, C7-12 aralkyl, or C6-10 aryl, Alk represents optionally substituted C2-10 alkylene {the substituent is hydroxy, C3-6 cycloalkyl, optionally substituted carbamoyl, or C6-10 aryl}, and p, q, r, and s each independently is 1, 2, or 3] or a pharmacologically acceptable salt or ester derivative of the compound. L'invention concerne un composé (ou bien un sel ou un ester pharmaceutiquement acceptable correspondant) représenté par la formule générale (I), dans laquelle R et R sont chacun indépendamment hydrogène ou alkyle C1-6, R est alkyle C1-15, cycloalkyle C3-7, ou aryle C6-10, et n vaut 1, 2 ou 3; X est soufre ou oxygène, et R , R , et R sont chacun indépendamment hydrogène, alkyle C1-6, hydroxy(alkyle C1-6), cycloalkyle C3-6, aralkyle C7-12, ou aryle C6-10. Alk est alkylène C2-10 éventuellement substitué (le substituant étant hydroxy, cycloalkyle C3-6, carbamoyle éventuellement substitué, ou aryle C6-10), et p, q, r, et s valent chacun indépendamment 1, 2, ou 3.