COMPOSITION FOR TREATING CANCER CONTAINING N,N-DIMETHYLPHYTOSPHINGOSINE

• Main Authors: PARK, CHANG-YEOL, PARK, CHANG-SEO, KOH, UIAN, HWANG, YOU-A, CHOI, JIN-HEE, KIM, EUN-JU, KIM, JIN-WOOK
• Format: Patent
• Language: English; French
• Published: 13.11.2003
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A composition and a kit for treating cancer comprising N, N-dimethylphytosphingosine. The composition represses the activity of sphingosine kinase, and therefore, intercepts various mechanisms which sphingosine kinase induces. For example, the composition blocks the phosphorylation of ceramide and sphingosine, thereby maintaining high concentration of ceramide and sphingosine. The ceramide and sphingosine induce apoptosis in cancer cells. Therefore, the composition according to the present invention induces apoptosis in cancer cells and accordingly kills the cancer cells. L'invention concerne une composition et un kit permettant de traiter un cancer contenant N,N-dimethylphytosphingosine. Ladite composition peut refouler l'activité de la sphingosine kinase et de ce fait, intercepter des mécanismes variés induits par ladite sphingosine kinase. La composition peut, par exemple, bloquer la phosphorylation de la céramide et de la sphingosine, ce qui permet de maintenir une concentration très élevée en céramide et en sphingosine. Lesdites céramide et sphingosine induisent une apoptose dans des cellules cancéreuses. La composition de l'invention peut donc induire une apoptose dans des cellules cancéreuses et tuer lesdites cellules.