N-SUBSTITUTED-HETEROARYLOXY-ARYL-SPIRO-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS

The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine- 2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G are as defined in the specification; and to pharmaceutical compositions and meth...

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Bibliographic Details
Main Authors FREEMAN-COOK, KEVIN, DANIEL, NOE, MARK, CARL
Format Patent
LanguageEnglish
French
Published 06.11.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine- 2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders. La présente invention concerne des inhibiteurs de la métalloprotéinase N-substitués-hétéroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione, représentés par la formule suivante dans laquelle le noyau X est un noyau hétérocyclique à 5-7 chaînons, et dans laquelle A, Y, B, et G sont tels que définis dans les spécifications. L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement de l'inflammation, du cancer et d'autres troubles.
Bibliography:Application Number: WO2003IB01508