CARTILAGE REGENERATION USING CHONDROCYTE AND TGF-beta

The present application is directed to a method of treating osteoarthritis, which includes obtaining a member of a transforming growth factor superfamily of proteins; obtaining a population of cultured connective tissue cells that may contain vector encoding a gene, or a population of cultured conne...

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Bibliographic Details
Main Authors YOUNGSUK, YI, SUN, UK, SONG, MOON, JONG, NOH, KWAN, HEE, LEE, DUG, KEUN, LEE
Format Patent
LanguageEnglish
French
Published 25.09.2003
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present application is directed to a method of treating osteoarthritis, which includes obtaining a member of a transforming growth factor superfamily of proteins; obtaining a population of cultured connective tissue cells that may contain vector encoding a gene, or a population of cultured connective tissue cells that do not contain any vector encoding a gene; and then transferring the protein and the connective tissue cells into an arthritic joint space of a mammalian host, such that the activity of the combination within the joint space results in regenerating connective tissue. L'invention porte sur un procédé de traitement de l'ostéoarthtose consistant: à obtenir une protéine membre de la superfamille des facteurs de croissance transformants; à obtenir une population de cellules de tissus conjonctifs de culture pouvant contenir un vecteur codant pour un gène ou une population de cellules de tissus conjonctifs de culture ne contenant aucun vecteur codant pour un gène; puis à transférer les protéines et les tissus conjonctifs dans l'espace d'une articulation arthritique de mammifère pour que l'activité de la combinaison y produise une regénération des tissus conjonctifs.
Bibliography:Application Number: WO2003US07486