METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS

Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extention to increase drying time, such improvements leading to the formation of homogeneous solid dispertions of drugs in concentration-en...

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Main Authors DEIBELE, HEATHER, LYNN, MELCHER, RAY, RODERICK, JACK, BEYERINCK, RONALD, ARTHUR, SPENCE, KENNY, RAY, DOBRY, DANIEL, ELMONT, SETTELL, DANA, MARIE
Format Patent
LanguageEnglish
French
Published 07.08.2003
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extention to increase drying time, such improvements leading to the formation of homogeneous solid dispertions of drugs in concentration-enhancing polymers. Selon l'invention, pour améliorer les procédés classiques de séchage par pulvérisation, on incorpore une buse de projection et une plaque diffuseuse afin d'améliorer l'écoulement du gaz de séchage et un prolongement de la chambre de séchage afin d'augmenter le temps de séchage, ces améliorations entraînant la formation de dispersions solides homogènes de médicaments dans des polymères renforçant la concentration.
Bibliography:Application Number: WO2003IB00144