PROLINE COMPOUNDS AS NS3-SERINE PROTEASE INHIBITORS FOR USE IN TREATMENT OF HEPATITES C VIRUS INFECTION

• Main Authors: BENNETT, FRANK, ARASAPPAN, ASHOK, VENKATRAMAN, SRIKANTH, LOVEY, RAYMOND, G, BOGEN, STEPHANE, L, GIRIJAVALLABHAN, VIYYOOR, M, LIU, YI-TSUNG, NJOROGE, F., GEORGE, MADISON, VINCENT, S, CHEN, KEVIN, X, NAIR, LATHA, G, SAKSENA, ANIL, K, JAO, EDWIN, SANNIGRAHI, MOUSUMI
• Format: Patent
• Language: English; French
• Published: 31.07.2003
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention discloses novel compounds of Formula I which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease. La présente invention concerne de nouveaux composés représentés par la formule I, présentant une activité d'inhibition de la protéase du VHC, ainsi que des méthodes de préparation de ces composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant de tels composés ainsi que des méthodes d'utilisation de ceux-ci dans le traitement des troubles associés à la protéase du VHC.