INTERMEDIATES FOR PREPARING GLYCOGEN PHOSPHORYLASE INHIBITORS

The instant invention provides novel processes and intermediates useful in the preparation of certain N-indole-2-carbonyl-beta-alaninamide compounds, which compounds are glycogen phosphorylase inhibitors useful in the treatment of diseases such as hypercholesterolemia, hyperglycemia, hyperinsulinemi...

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Main Authors BUSCH, FRANK, ROBERT, COUTURIER, MICHEL, ANDRE, BARRILA, MARK, THOMAS, ORRILL, SUSAN, LEE, ROSE, PETER, ROBERT, TOBIASSEN, HARRY, ODD, TICKNER, DEREK, LAWRENCE, WITHBROE, GREGORY, JOHN
Format Patent
LanguageEnglish
French
Published 24.07.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The instant invention provides novel processes and intermediates useful in the preparation of certain N-indole-2-carbonyl-beta-alaninamide compounds, which compounds are glycogen phosphorylase inhibitors useful in the treatment of diseases such as hypercholesterolemia, hyperglycemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis, diabetes, diabetic cardiomyopathy, infection, tissue ischemia, myocardial ischemia, and in inhibiting tumor growth. L'invention concerne de nouveaux procédés et intermédiaires utiles dans la préparation de certains composés N-(indole-2-carbonyl)- beta -alaninamide, ces composés étant des inhibiteurs de phosphorylase glycogène utiles dans le traitement de maladies telles que l'hypercholestérolémie, l'hyperglycémie, l'hyperinsulinémie, l'hyperlipidémie, l'hypertension, l'athérosclérose, le diabète, la cardiomyopathie diabétique, l'infection, l'ischémie tissulaire, l'ischémie myocardique, et permettant d'inhiber la croissance tumorale.
Bibliography:Application Number: WO2003IB00034