AMORPHOUS SUBSTANCE OF TRICYCLIC TRIAZOLOBENZAZEPINE DERIVATIVE

• Main Authors: UDAGAWA, CHIKAKO, SUEMUNE, KENJI, ISHIWATA, MAYUMI, ISHIZAWA, TAKAYUKI, ISHIKURA, TOYOAKI
• Format: Patent
• Language: English; French; Japanese
• Published: 10.07.2003
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Amorphous 2-1-isopropoxycarbonyloxy-2-methylpropyl-7,8-dimethoxy-45H,10-dioxo-2H -1,2,3-triazolo[4,5-c][1]benzazepine, which is improved in absorbability and solubility and a medicinal composition containing the compound. Also provided are processes for producing amorphous 2-1-isopropoxycarbonyloxy-2-methylpropyl-7,8-dimethoxy-45H,10-dioxo-2H -1,2,3-triazolo[4,5-c][1]benzazepine and for producing a medicinal composition containing the compound. Amorphous 2-1-isopropoxycarbonyloxy-2-methylpropyl-7,8-dimethoxy-45H,10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which is improved in absorbability and solubility and a medicinal composition containing the compound. Also provided are processes for producing amorphous 2-1-isopropoxycarbonyloxy-2-methylpropyl-7,8-dimethoxy-45H,10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine and for producing a medicinal composition containing the compound. L'invention porte sur 2-(1-isopropoxycabonyloxy-2-méthylpropyl)-7,8-diméthoxy-4(5H), 10-dioxo-2H-1, 2, 3-triazolo[4,5-c] [1]benzazépine amorphe dont l'absorbabilité et la solubilité sont améliorées. L'invention porte également sur une composition médicinale contenant le composé. L'invention porte, en outre, sur des procédés de production de 2-(1-isopropoxycabonyloxy-2-méthylpropyl)-7,8-diméthoxy-4(5H), 10-dioxo-2H-1, 2, 3-triazolo[4,5-c] [1]benzazépine amorphe et d'une composition médicinale contenant le composé.