NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME

• Main Authors: DIPIPPO, VINCENT, A, CHANT, JOHN, S, BERGHS, CONSTANCE, EDINGER, SHLOMIT, R, ALSOBROOK, JOHN, P., II, AGEE, MICHELE, L, BURGESS, CATHERINE, E, EISEN, ANDREW, BOLDOG, FERENC, L, CHAUDHURI, AMITABHA
• Format: Patent
• Language: English; French
• Published: 15.05.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins. L'invention concerne des nouveaux polynucléotides isolés et des polypeptides cibles de petites molécules codés par lesdits polynucléotides. L'invention concerne également des anticorps qui se fixent de manière immunospécifique sur un nouveau polypeptide cible de petite molécule ou sur tout dérivé, variant, mutant ou fragment dudit polypeptide, polynucléotide ou anticorps, ainsi que des procédés utilisant lesdits polypeptide cible de petite molécule, polynuléotide ou anticorps dans la détection et le traitement d'une grande variété d'états pathologiques. L'invention concerne plus particulièrement des procédés d'utilisation de protéines exprimées par recombinaison et/ou de manière endogène dans diverses techniques de criblage, pour identifier des anticorps thérapeutiques et des petites molécules thérapeutiques associés à des maladies. L'invention concerne encore des méthodes thérapeutiques, diagnostiques et de recherche utilisées pour diagnostiquer, traiter et prévenir des troubles impliquant un de ces nouveaux acides nucléiques et protéines humaines.