QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

The invention concerns quinazoline derivatives of Formula (I); wherein each of Q , Q , Z, R , R , R , L and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in...

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Bibliographic Details
Main Authors BRADBURY, ROBERT, HUGH, HENNEQUIN, LAURENT, FRANCOIS, ANDRE, KETTLE, JASON, GRANT, PASS, MARTIN
Format Patent
LanguageEnglish
French
Published 15.05.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention concerns quinazoline derivatives of Formula (I); wherein each of Q , Q , Z, R , R , R , L and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases. L'invention porte sur des dérivés se la quinazoline de formule (I) dans laquelle: Q , Q , Z, R , R , R , L et m ont l'une des significations définies dans la description; sur leur procédé de préparation sur des préparations pharmaceutiques les contenant et sur leur utilisation dans la fabrication de médicaments servant à la prévention ou au traitement de tumeurs sensibles à l'inhibition des tyrosine-kinases réceptrices de la famille des erbB.
Bibliography:Application Number: WO2002GB04932