MEDICINAL COMPOSITION FOR PREVENTION OF OR TREATMENT FOR CEREBROVASCULAR DISORDER AND CARDIOPATHY

• Main Authors: SATOH, SHIN-ICHI, HITOMI, ASAKO, TOSHIMA, YOSHINORI, IKEGAKI, ICHIRO
• Format: Patent
• Language: English; French; Japanese
• Published: 27.03.2003
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A medicinal composition comprising: (a) a compound represented by the following general formula (I): (I) (wherein R1 represents hydrogen or hydroxy) or an acid addition salt or hydrate of the compound; and (b) at least one member selected from the group of acceptable drugs consisting of a cerebral vasodilator, vasodilator agent, brain−protective agent, cerebral metabolism activator, anticoagulant agent, antithrombocytic agent, thrombolytic agent, alleviator for mental disorders, hypotensive drug, remedy for angina pectoris, diuretic agent, cardiac restorative, antiarrhythmic agent, hyperlipemia remedy, and immunosuppressant. It is useful as a preventive or remedy for cerebrovascular disorders and cardiopathy. A medicinal composition comprising: a a compound represented by the following general formula I: I wherein R1 represents hydrogen or hydroxy or an acid addition salt or hydrate of the compound and b at least one member selected from the group of acceptable drugs consisting of a cerebral vasodilator, vasodilator agent, brain-protective agent, cerebral metabolism activator, anticoagulant agent, antithrombocytic agent, thrombolytic agent, alleviator for mental disorders, hypotensive drug, remedy for angina pectoris, diuretic agent, cardiac restorative, antiarrhythmic agent, hyperlipemia remedy, and immunosuppressant. It is useful as a preventive or remedy for cerebrovascular disorders and cardiopathy. L'invention concerne une composition médicinale comprenant: (a) un composé de formule (I) dans laquelle R1 représente hydrogène ou hydroxy, ou un sel d'addition acide ou un hydrate dudit composé; et (b) au moins un élément sélectionné dans le groupe des médicaments acceptables comprenant un vasodilatateur cérébral, un agent vasodilatateur, un agent protecteur cérébral, un activateur de métabolisme cérébral, un agent anticoagulant, un agent anti-thrombotique, un agent thrombolytique, un agent apaisant les troubles mentaux, un médicament hypotenseur, un remède contre l'angine de poitrine, un agent diurétique, un reconstituant cardiaque, un agent antiarythmique, un remède contre l'hyperlipémie, et un immunosuppresseur. Ladite composition est utile à des fins de prévention ou de remède contre les troubles vasculaires cérébraux et la cardiopathie.