NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME

• Main Authors: DIPIPPO, VINCENT, A, LEPLEY, DENISE, M, GERLACH, VALERIE, L, BERGHS, CONSTANCE, MALYANKAR, URIEL, M, ZHONG, MEI, ELLERMAN, KAREN, ALSOBROOK, JOHN, P., II, BURGESS, CATHERINE, E, LEACH, MARTIN, D, ROTHENBERG, MARK, E, LIU, XIAOHONG, VERNET, CORINE, A., M, SHENOY, SURESH, G, TWOMLOW, NANCY, GUO, XIAOJIA, JI, WEIZHEN, VOSS, EDWARD, Z, CHANT, JOHN, S, ANDERSON, DAVID, W, LI, LI, SPADERNA, STEVEN, K, TAUPIER, RAYMOND, J., JR, KEKUDA, RAMESH, MILLER, CHARLES, E, OOI, CHEAN, ENG, GIOT, LOIC, EDINGER, SHLOMIT, R, ZERHUSEN, BRYAN, D, PENA, CAROL, E., A, SHIMKETS, RICHARD, A, SPYTEK, KIMBERLY, A, CHAUDHURI, AMITABHA, CATTERTON, ELINA, PATTURAJAN, MEERA, CRABTREE, JULIE, CASMAN, STACIE, J, ORT, TATIANA, GORMAN, LINDA, GUSEV, VLADIMIR, Y, AGEE, MICHELE, L, GANGOLLI, ESHA, A, RIEGER, DANIEL, K, PADIGARU, MURALIDHARA, EISEN, ANDREW, BOLDOG, FERENC, L, KHRAMTSOV, NIKOLAI, V
• Format: Patent
• Language: English; French
• Published: 06.12.2007
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins. L'invention concerne de nouveaux polynucléotides isolés et des polypeptides cibles de petites molécules codés par ces polynucléotides. L'invention concerne également des anticorps qui se fixent de manière immunospécifique sur un nouveau polypeptide cible de petite molécule ou sur tout dérivé, variant, mutant ou fragment dudit polypeptide, polynucléotide ou anticorps, ainsi que des méthodes utilisant lesdits polypeptide cible de petite molécule, polynucléotide et anticorps dans la détection et le traitement d'un large éventail d'états pathologiques. L'invention concerne plus particulièrement des méthodes utilisant des protéines exprimées par recombinaison et/ou de manière endogène, dans divers procédés de criblage servant à identifier des anticorps thérapeutiques et des petites molécules thérapeutiques associés à ces maladies. L'invention concerne enfin des méthodes thérapeutiques et diagnostiques et des méthodes de recherche permettant le diagnostic, le traitement et la prévention de troubles impliquant un de ces nouveaux acides nucléiques ou protéines humaines.