2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF

• Main Authors: GOLDMAN, PHYLLIS, SONG, REN, HUA, DAHL, RUSSELL, S, FOWLER, KERRY, W, BOURDON, LISA, H, RUETER, JAIMIE, K, DEMAGGIO, ANTHONY, J, HERENDEEN, DAN, HUANG, DANWEN, REISCH, HELGE, A, MOREE, WILNA, J, CHRISTENSON, ERIK, BERTINO, JAIMIE, A, MCELLIGOTT, DAVID, L, FAIRFAX, DAVID, J, ZHICHKIN, PAVEL, E, BEATON, GRAHAM, JIANG, QIN
• Format: Patent
• Language: English; French
• Published: 27.02.2003
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides compounds comprising a bicyclic aryl moiety, such as 2H-phthalazin-1-one or derivatives thereof, compositions comprising the same, and methods for producing and using the same. In particular, the present invention provides compounds of the formula: (I) or a pharmaceutically acceptable salt, a hydrate, a solvate, or a prodrug thereof; where Q , Q and Y are those defined herein. L'invention concerne des composés comprenant une fraction aryle bicyclique, p. ex. 2H-phtalazine-1-one ou ses dérivés, des compositions contenant ces composés et des procédés de production et d'utilisation de ceux-ci. Elle concerne en particulier des composés représentés par la formule (I) ou un sel pharmaceutiquement acceptable, un hydrate, un solvate, ou un promédicament de ceux-ci, Q , Q et Y étant définis dans la demande.