NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME

• Main Authors: DIPIPPO, VINCENT, A, BERGHS, CONSTANCE, CASMAN, STACIE, J, EDINGER, SHLOMIT, R, ANDERSON, DAVID, W, ELLERMAN, KAREN, AGEE, MICHELE, L, GANGOLLI, ESHA, A, EISEN, ANDREW, CATTERTON, ELINA
• Format: Patent
• Language: English; French
• Published: 03.01.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; TESTING; VINEGAR; WINE

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. La présente invention concerne de nouveaux polynucléotides isolés et des polypeptides cibles à petites molécules codés par les polynucléotides. L'invention concerne également des anticorps de liaison immunospécifique au polypeptide cible à petites molécules ou tout dérivé, variant, mutant ou fragment dudit polypeptide, polynucléotide ou anticorps ainsi que des procédés dans lesquels le polypeptide cible, polynucléotide et anticorps sont utilisés dans la détection et le traitement d'une large gamme de conditions pathologiques. Plus précisément, la présente invention décrit des procédés d'utilisation de protéines exprimées de manière recombinante et/ou endogène dans divers procédés permettant l'identification d'anticorps thérapeutiques et de petites molécules thérapeutiques associés aux maladies.