CHEMICALLY-MODIFIED PROGENIPOIETIN CONJUGATES

The present invention provides a chemically modified Progenipoietins (ProGPs) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting neutrophil-increasing activity than that of the un-modified ProG...

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Bibliographic Details
Main Authors HILLS, ROBERT, L, SIEGEL, NED, R, FINN, RORY, F
Format Patent
LanguageEnglish
French
Published 11.12.2003
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides a chemically modified Progenipoietins (ProGPs) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting neutrophil-increasing activity than that of the un-modified ProGP, enabling reduced dose and scheduling opportunities. L'invention concerne des protéines </= PROGENIPOIETIN >/= (ProGP) chimiquement modifiées, préparées par la liaison d'un polymère soluble dans l'eau à ladite protéine. La protéine chimiquement modifiée selon l'invention peut présenter une activité d'augmentation des neutrophiles dont la durée est beaucoup plus importante que celle du ProGP non modifié, ce qui permet d'obtenir des doses réduites et des possibilités de programmation accrues.
Bibliography:Application Number: WO2002US18810