ONCOLYTIC VIRUS

Methods of reducing the viability of a tumor cell, infecting a neoplasm in a mammal with a virus, or treating a neoplasm in a mammal, utilizing certain non-naturally occuring viruses are disclosed. Viral reassortants, for example reovirus reassortants, and techniques for identifying PKR-sensitive vi...

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Bibliographic Details
Main Authors BELL, JOHN, CAMERON, BROWN, EARL, GARNET
Format Patent
LanguageEnglish
French
Published 28.11.2002
Edition7
Subjects
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Summary:Methods of reducing the viability of a tumor cell, infecting a neoplasm in a mammal with a virus, or treating a neoplasm in a mammal, utilizing certain non-naturally occuring viruses are disclosed. Viral reassortants, for example reovirus reassortants, and techniques for identifying PKR-sensitive viruses are also disclosed. L'invention concerne des procédés servant à limiter la viabilité d'une cellule cancéreuse, à infecter une tumeur par un virus chez un mammifère ou à traiter une tumeur chez un mammifère au moyen de certains virus artificiels. Elle concerne également des virus réassortis, par exemple, des réovirus réassortis, ainsi que des techniques servant à identifier des virus sensibles à PKR.
Bibliography:Application Number: WO2001US45108