ONCOLYTIC VIRUS

Methods of reducing the viability of a tumor cell, infecting a neoplasm in a mammal, utilizing certain non-naturally occuring viruses are disclosed. Viral reassortants, for example reovirus reassortants, and techniques for identifying PKR-sensitive viruses are also disclosed. L'invention concer...

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Bibliographic Details
Main Authors BELL, JOHN, CAMERON, BROWN, EARL, GARNET, STODJL, DAVID, FRANCIS, MBISA, JEAN, LUTAMYO
Format Patent
LanguageEnglish
French
Published 06.06.2002
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Methods of reducing the viability of a tumor cell, infecting a neoplasm in a mammal, utilizing certain non-naturally occuring viruses are disclosed. Viral reassortants, for example reovirus reassortants, and techniques for identifying PKR-sensitive viruses are also disclosed. L'invention concerne des méthodes de réduction de la viabilité d'une cellule tumorale, par l'infection par un virus d'un néoplasme chez un mammifère ou par le traitement d'un néoplasme chez un mammifère, au moyen de certains virus non naturels. Des réassortiments viraux, comme, par exemple des réassortiments réoviraux, et des techniques d'identification des virus sensibles à PKR sont également décrits.
Bibliography:Application Number: WO2001CA01703