METHODS INVOLVING A T CELL PROTEIN TYROSINE PHOSPHATASE

• Main Authors: SIMONCIC, PAUL, DANIEL, TREMBLAY, MICHAEL, MCGLADE, JANE, C
• Format: Patent
• Language: English; French
• Published: 31.10.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

This invention relates to T cell protein tyrosine phosphatase (TCPTP) and more particularly to its role in cell signaling and interaction with the JAK family of tyrosine kinases. In particular, the invention involves the use of TCPTP for the development of treatments for malignancies and autoimmune conditions involving inappropriate JAK kinase signaling as well as for the identification of inhibitors and activators of this phosphatase. Cette invention concerne la protéine tyrosine phosphatase de lymphocyte T (TCPTP) et singulièrement son rôle dans la signalisation cellulaire et son interaction avec la famille JAK des tyrosine kinases. L'invention concerne en particulier l'utilisation de TCPTP pour l'élaboration de traitement de tumeurs malignes et de maladies auto-immunes en rapport avec une signalisation inadéquate des kinases JAK ainsi que pour l'identification d'inhibiteurs et d'activateur de cette phosphatase.