NUCLEIC ACID SEQUENCES DIFFERENTIALLY EXPRESSED IN CANCER TISSUE

• Main Authors: THIAGLINGAM, ARUNTHATHI, CARROLL, EDDIE, III, LEWIS, MARCIA, E, BURGESS, CHRISTOPHER, ASTLE, JOHN, H, CATINO, THEODORE, J, MOLINO, GARY, A, DWIVEDI, POORNIMA
• Format: Patent
• Language: English; French
• Published: 11.04.2002
• Edition: 7
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

This invention relates to novel nucleic acid sequences which are differentially expressed in cancer cells. The invention also relates to proteins and peptides encoded by the sequences, to diagnostic assays and therapeutic agents based on the sequences and proteins, and to probes, antisense constructs, and antibodies derived from the sequences and proteins or peptides. The subject nucleic acids have been found to be differentially expressed by tumor cells, particularly in colon cancer tissue. L'invention se rapporte à de nouvelles séquences d'acide nucléique qui sont différentiellement exprimées dans des cellules cancéreuses. Cette invention concerne également des protéines et des peptides codés par lesdites séquences, des méthodes diagnostiques et des agents thérapeutiques basés sur ces séquences et ces protéines, des sondes, des constructions anti-sens ainsi que des anticorps dérivés des séquences et des protéines ou des peptides. Les acides nucléiques susmentionnés se sont révélés être différentiellement exprimés par les cellules tumorales, particulièrement dans le tissu cancéreux du côlon.