MACROCYCLES USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention are macrocycles of the formula (IX), for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of...

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Bibliographic Details
Main Authors PULLEY, SHON, R, BECK, JAMES, P, TENBRINK, RUTH, E
Format Patent
LanguageEnglish
French
Published 19.12.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention are macrocycles of the formula (IX), for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation. L'invention concerne des macrocycles de la formule (IX) suivante destinés au traitement de la maladie d'Alzheimer et d'autres maladies similaires. Ces composés comprennent des inhibiteurs de l'enzyme beta-sécrétase utilisés dans le traitement de la maladie d'Alzheimer et d'autres maladies se caractérisant par le dépôt du peptide beta A chez un mammifère. Les composés selon l'invention sont utilisés dans des compositions pharmaceutiques et des procédés de traitement permettant de réduire la formation du peptide beta A.
Bibliography:Application Number: WO2002US19076