1,2-DIPHENYL-1-NAPHTHYL ETHENE DERIVATIVES, ANALOGS AND USE THEREOF

Molecules of Formula (I), epithelial cancer cell lines, human estrogen-dependent cancer cells and endothelial cells are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of various cancers. The compounds specified are 1,2-diphenyl-1-naphthyl ethene derivativ...

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Main Authors WHELAN, JOHN, MERCURE, JULIE, LAZAROWYCH, NATALIE, SCHMIDT, JONATHAN, MARTIN, ZHU, SHUGUANG
Format Patent
LanguageEnglish
French
Published 29.08.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Molecules of Formula (I), epithelial cancer cell lines, human estrogen-dependent cancer cells and endothelial cells are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of various cancers. The compounds specified are 1,2-diphenyl-1-naphthyl ethene derivatives. Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines, human estrogen-dependent cancer cells and endothelial cells are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of various cancers. The compounds specified are 1,2-diphenyl-1-naphthyl ethene derivatives. L'invention concerne des molécules présentant des effets anti-prolifératifs contre des lignées cellulaires cancéreuses épithéliales, des cellules cancéreuses humaines dépendantes des oestrogènes et des cellules endothéliales. Les molécules sont destinées à être utilisées dans des préparations thérapeutiques pour le traitement de différents cancers. Les composés spécifiés sont des dérivés de 1,2-diphényl-1-naphtyl éthène.
Bibliography:Application Number: WO2002CA00226