POLYNUCLEOTIDES ENCODING HUMAN PHOSPHATASES

• Main Authors: BASSOLINO, DONNA, MINTIER, GABE, LEE, LIANA, BOL, DAVID, JACKSON, DONALD, G, SCHIEVEN, GARY, BANAS, DANA, SIEMERS, NATHAN, NELSON, THOMAS, KRYSTEK, STANLEY, SUCHARD, SUSAN, FINGER, JOSHUA, FEDER, JOHN, MCATEE, PATRICK, RAMANATHAN, CHANDRA, TODDERUD, C, GORDON
• Format: Patent
• Language: English; French
• Published: 10.04.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CALCULATING; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; COMPUTING; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; COUNTING; CULTURE MEDIA; ELECTRIC DIGITAL DATA PROCESSING; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. L'invention concerne de nouveaux polynucléotides codant pour des polypeptides phosphatase humains, des fragments et des homologues de ces derniers. L'invention concerne également des vecteurs, des cellules hôtes, des anticorps et des procédés de recombinaison et de synthèse pour produire ces polypeptides. L'invention concerne en outre des méthodes diagnostiques et thérapeutiques pour appliquer ces nouveaux polypeptides phosphatase humains au diagnostic, au traitement et/ou à la prévention de diverses maladies et/ou de divers troubles associés à ces polypeptides, notamment des maladies et/ou troubles cardiovasculaires. L'invention concerne enfin des procédés de criblage destinés à identifier des agonistes et des antagonistes des polynucléotides et des polypeptides de la présente invention.