HETERO-TRICYCLIC COMPOUNDS HAVING SUBSTITUTED AMINO GROUPS

Compounds represented by the general formula (¦), which exhibit excellent immunosuppressive and/or antiallergic effects and are useful as drugs: (¦) wherein X is N or CR ; Y is N or CR ; Z is N or CR ; R , R , R , and R are each independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lowe...

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Bibliographic Details
Main Authors TAKECHI, SHOZO, TSURI, TATSUO, HORIBE, ISAO
Format Patent
LanguageEnglish
French
Japanese
Published 25.07.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds represented by the general formula (¦), which exhibit excellent immunosuppressive and/or antiallergic effects and are useful as drugs: (¦) wherein X is N or CR ; Y is N or CR ; Z is N or CR ; R , R , R , and R are each independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkylsulfonyl, cycloalkyl, or the like; and R to R are each hydrogen, halogeno, hydroxyl, lower alkyl, lower alkoxy, acyl, carboxyl, lower alkoxycarbonyl, or the like. Compounds represented by the general formula (|), which exhibit excellent immunosuppressive and/or antiallergic effects and are useful as drugs: (|) wherein X is N or CR ; Y is N or CR ; Z is N or CR ; R , R , R , and R are each independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkylsulfonyl, cycloalkyl, or the like; and R to R are each hydrogen, halogeno, hydroxyl, lower alkyl, lower alkoxy, acyl, carboxyl, lower alkoxycarbonyl, or the like. L'invention concerne les composés de la formule générale (I), lesdits composés présentant d'excellents effets immunosuppressifs et/ou antiallergiques, et servant d'agents pharmaceutiques. Dans ladite formule, X est N ou CR ; Y est N ou CR ; Z est N ou CR ; R , R ,< >R ,< >et R sont indépendamment l'un de l'autre hydrogène, alkyle de faible masse moléculaire, alcényle de faible masse moléculaire, alcynyle de faible masse moléculaire, alkylsulfonyle de faible masse moléculaire, cycloalkyle ou similaires ; et, R à R sont hydrogène, halogéno, hydroxyle, alkyle de faible masse moléculaire, alkoxy de faible masse moléculaire, acyle, carboxyle, alkoxycarbonyle de faible masse moléculaire ou similaires.
Bibliography:Application Number: WO2002JP00260