MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES)

The present invention provides novel thienopyridines, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP; wherein X, R1, R2, R3 and R4 are defined more fully in the description. The compounds are usef...

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Bibliographic Details
Main Authors ANDERSEN, HENRIK, SUNE, HANSEN, THOMAS, KRUSE, AXE, FRANK, URBAN, LAU, JESPER, SHAPIRA, BARRY, ZVI, JUDGE, LUKE, MILBURN, UYEDA, ROY, TERUYUKI, OLSEN, OLE, HVILSTED, HOLSWORTH, DANIEL, DALE, GE, YU, BAKIR, FARID, NEWMAN, MICHAEL, JAMES, MOELLER, NIELS PETER, HUNDAHL
Format Patent
LanguageEnglish
French
Published 17.01.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides novel thienopyridines, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP; wherein X, R1, R2, R3 and R4 are defined more fully in the description. The compounds are useful in the treatment of type diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases. L'invention concerne des nouvelles thiénopyridines, de tels composés de formule 1 étant utiles sur le plan pharmaceutique comme inhibiteurs des protéines tyrosines phosphatases (PTPASES) comprenant PTP1B, une cellule T de PTP; dans laquelle X, R1, R2, R3 et R4 sont définis de manière complète dans la description. Ces composés sont utiles pour le traitement des diabètes de type 1 et 2, de la tolérance altérée au glucose, de la résistance à l'insuline, de l'obésité et d'autres maladies.
Bibliography:Application Number: WO2001DK00451