ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND MATERIALS FOR THEIR SYNTHESIS

• Main Authors: HUA, YE, REICH, SIEGFRIED, HEINZ, SKALITZKY, DONALD, JAMES, LUU, HIEP, THE, HENDRICKSON, THOMAS, F, CHAN, FORA, P, YANG, YI, EASTMAN, BRIAN, WALTER, JOHNSON, THEODORE, O., JR, CHU, SHAO, SONG
• Format: Patent
• Language: English; French
• Published: 10.07.2003
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of the formula (I), where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described. L'invention concerne des composés représentés par la formule (I) dans laquelle les variables sont telles que définies dans le descriptif, qui inhibent ou bloquent avantageusement l'activité biologique de la protéase 3C picornavirale. Ces composés, ainsi que des compositions pharmaceutiques contenant ceux-ci, sont utiles pour traiter des patients ou des hôtes infectés par un ou plusieurs picornavirus, p. ex. RVP. L'invention concerne aussi des produits intermédiaires et des procédés de synthèse pour préparer ces composés.