ASSAY FOR DETECTION OF TRANSFERASE ENZYME ACTIVITY IN DRUG SCREENING

The invention provides methods for assaying the activity of the translocase enzyme and/or transferase enzyme involved in peptidoglycan biosynthesis in bacteria using scintillation proximity assay methodology. The methods are suitable for high throughput screening of potential anti-bacterial drugs. L...

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Bibliographic Details
Main Authors DESOUSA, SUNITA, MARIA, SOLAPURE, SURESH
Format Patent
LanguageEnglish
French
Published 13.12.2001
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The invention provides methods for assaying the activity of the translocase enzyme and/or transferase enzyme involved in peptidoglycan biosynthesis in bacteria using scintillation proximity assay methodology. The methods are suitable for high throughput screening of potential anti-bacterial drugs. L'invention concerne des procédés permettant de tester l'activité de l'enzyme translocase et/ou l'enzyme transférase impliquées dans la biosynthèse de peptidoglycane de bactéries selon par un processus de dosage de la scintillation par proximité. Les procédés conviennent au tri haut à rendement de drogues antibactériennes potentielles.
Bibliography:Application Number: WO2001SE01271