(BIS)SULFONAMIDE DERIVATIVES

• Main Authors: KNOBELSDORF, JAMES, ALLEN, ZARRINMAYEH, HAMIDEH
• Format: Patent
• Language: English; French
• Published: 23.05.2002
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides bissulphonamide derivatives of formula (I), in which R represents C1-6-alkyl, C2-6-alkenyl, or NR R ,R and R each independently represent hydrogen, C1-4.alkyl, F, aryl, or C1-6.alkylaryl; R and R each represent hydrogen; R represents C1-6-alkyl; n is an integer from 7 to 14; and R and R each independently represent hydrogen or C1-4-alkyl; or a pharmaceutically acceptable salt thereof. Bissulphonamide derivatives of formula (I), in which R represents C1-6-alkyl, C2-6-alkenyl, or NR R , R , R , R , and R each represent hydrogen; R represents C1-6-alkyl; n is an integer from 6 to 14; and R and R each independently represent hydrogen or C1-4-alkyl; or a pharmaceutically acceptable salt thereof; are useful for potentiating glutamate receptor function in a mammal and, therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. La présente invention concerne des dérivés de (bis)sulfonamide représentés par la formule (I) qui conviennent pour potentialiser la fonction du récepteur de glutamate chez un mammifère et qui convient, par conséquent, pour traiter une grande variété de pathologies, telles que des troubles psychiatriques et neurologiques.