COMPOSITIONS AND METHODS FOR TREATING NEOPLASTIC DISEASE USING INHIBITORS OF LAMININ5BETA3

• Main Authors: JEFFERSON, ANNE, B, DEN-OTTER, DOUGLAS, R, REINHARD, CHRISTOPH, J, WINTER, JILL, A
• Format: Patent
• Language: English; French
• Published: 23.01.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Inhibitors of laminin5beta3 are provided that reduce the expression or biological activities of laminin5beta3 or the expression of laminin5beta3 mRNA in a mammalian cell. Laminin5beta3 inhibitors include antisense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. Laminin5beta3 inhibitors find use in compositions and methods for decreasing laminin5beta3 gene expression as well as methods for inhibiting the proliferation of mammalian cells, including tumor cells of epithelial origin, and methods for treating neoplastic diseases. L'invention concerne des inhibiteurs de laminine 5 bêta 3 qui réduisent l'expression ou les activités biologiques de laminine 5 bêta 3, ou l'expression d'ARNm de laminine 5 bêta 3 dans une cellule de mammifère. Les inhibiteurs de laminine 5 bêta 3 comprennent des molécules antisens, des ribozymes, des anticorps et des fragments d'anticorps, des protéines et des polypeptides ainsi que de petites molécules. Les inhibiteurs de laminine 5 bêta 3 sont utiles dans des compositions et des procédés visant à diminuer l'expression génique de laminine 5 bêta 3, dans des procédés d'inhibition de la prolifération de cellules de mammifère, y compris des cellules tumorales d'origine épithéliale, et dans des méthodes de traitement d'affections néoplasiques.