PARAOXONASE PON3 AND USES THEREOF

The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability of alter PON3 associat...

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Bibliographic Details
Main Authors DRAGANOVAGOMIR, I, STETSON, PHILIP, LA DU, BERT, N, WATSON, CATHERINE, E
Format Patent
LanguageEnglish
French
Published 03.10.2002
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to paraoxonase genes, in particular PON3. The present invention provides isolated nucleotide sequence encoding PON3, wild type and mutant PON3 peptides. The present invention also provides methods for using PON3 to screen compounds for the ability of alter PON3 associated activities, methods for generating antibodies useful in the detection of PON3, and methods of treating and preventing oxidative damage, sepsis, chemical toxicity, and other conditions. L'invention concerne des gènes paraoxonase, en particulier PON3. L'invention concerne des séquences nucléotidiques isolées codant pour PON3, pour des peptides PON3 mutants et de type sauvage. L'invention concerne également des procédés permettant d'utiliser PON3 pour cribler des composés de manière à permettre la modification des activités liées au PON3; des procédés permettant de produire des anticorps utiles à la détection du PON3, et des procédés permettant le traitement et la prévention du stress oxydatif, de la sepsie, de la toxicité chimique et d'autres affections.
Bibliography:Application Number: WO2001US16126