METHOD OF EXAMINING CANCER BY ASSAYING AUTOANTIBODY AGAINST MDM2 AND REAGENT THEREFOR

A novel method of examining cancer by assaying an autoantibody against MDM2 in the blood and a reagent and a kit therefor. For example, cancer is examined by an immunological method with the use of a peptide fragment of MDM2 as an antigen and anti-MDM2 antibody, which is optionally labeled, obtained...

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Bibliographic Details
Main Author SEINO, YUKO
Format Patent
LanguageEnglish
French
Japanese
Published 11.10.2001
Edition7
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:A novel method of examining cancer by assaying an autoantibody against MDM2 in the blood and a reagent and a kit therefor. For example, cancer is examined by an immunological method with the use of a peptide fragment of MDM2 as an antigen and anti-MDM2 antibody, which is optionally labeled, obtained from this antigen as an antibody for assaying the autoantibody as described above. Cette invention, qui a trait à une nouvelle technique d'investigation du cancer faisant appel à une épreuve biologique d'un autoanticorps contre MDM2 dans le sang, concerne également un réactif ainsi qu'un nécessaire à cet effet. On procède, notamment, à une recherche de cancer par voie immunologique, dans le cadre de laquelle on utilise un fragment peptidique de MDM2 en tant qu'antigène ainsi qu'un anticorps anti MDM2, lequel est éventuellement marqué, obtenu à partir de cet antigène comme anticorps et ce, pour soumettre l'autoanticorps susmentionné à une épreuve biologique.
Bibliography:Application Number: WO2001JP02723