CYTOKINE ACTIVITY REGULATOR MOLECULES FROM TICK SALIVARY GLANDS

• Main Authors: GA&SCARON, SLOVAK, MIRKO, FUCHSBERGER, NORBERT, HAJNICKA, VALERIA, KOCAKOVA, PAULA
• Format: Patent
• Language: English; French
• Published: 03.01.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to cytokine activity regulator molecules (CARMs) and their use in controlling the action of cytokines, particularly chemokines. In particular, the invention relates to CARMs that are derived from parasite salivary glands. The invention also relates to the use of CARMs in the treatment of diseases and allergies and in the production of vaccines that protect mammals, including humans, against the transmission of pathogenic (disease-causing) micro-organisms by certain parasites. La présente invention porte sur des molécules régulatrices de l'activité des cytokines (CARM) et leur utilisation dans la commande de l'action des cytokines, notamment des chimiokines. Plus précisément, l'invention concerne des CARM dérivées des glandes salivaires parasitaires. L'invention concerne également l'utilisation des CARM dans le traitement de maladies et d'allergies ainsi que dans la préparation de vaccins qui protègent les mammifères, notamment les êtres humains, contre la transmission de micro-organismes pathogènes (provoquant des maladies) par certains parasites.