NOVEL FAMILY OF PROTEINS, CALLED ATIP, NUCLEIC SEQUENCES CODING FOR SAME AND USES THEREOF

• Main Authors: STROSBERG, ARTHUR, DONNY, NOUET, SANDRINE, NAHMIAS, CLARA
• Format: Patent
• Language: English; French
• Published: 09.08.2001
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention concerns a novel family of human proteins (hATIP) interacting with the angiotensin II receptor and having an antioncogenic function. Said family of proteins is therefore useful for diagnosing cancer and pre-cancer conditions and for treating cancer conditions. The invention also concerns the gene coding for said proteins, fragments of said gene and the uses thereof for detecting and expressing said proteins. The invention further concerns antibodies directed against said proteins and methods for detecting and/or screening pre-cancer or cancer condition using said proteins, said antibodies and/or various nucleic acid sequences. Nouvelle famille de protéines humaines (hATIP), interagis-sant avec le récepteur AT2 de l'angiotensine II et possédant une fonction d'anti-oncogène. Ladite famille de protéines est donc utile pour le diagnostic des états cancéreux et précancéreux et le traitement des états cancéreux. Gène codant pour lesdites protéines, fragments dudit gène et leurs applications pour la détection et l'expression desdites protéines. Anticorps dirigés contre lesdites protéines ainsi qu'à des procédés de détection et/ou de dépistage d'un état précancéreux ou cancéreux à l'aide desdites protéi nes desdits anticorps et/ou des différentes séquences d'acides nucléiques.