TREATMENT FOR INFLAMMATORY BOWEL DISEASE (IBD) AND RELATED CONDITIONS

• Main Authors: HOFFMAN, KEITH, BASU, AMARESH
• Format: Patent
• Language: English; French
• Published: 28.06.2001
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compositions, including formulations, of plants for the treatment of Inflammatory Bowel Disease, Irritable Bowel Syndrome, and inflammatory and other related conditions, such as arthritis, are disclosed. The formulations consist of one or both of the two herbs Chen Pi Citrus reticulata and Wu Mei Prunus mume, which, according to the invention, possess significant cytokine TNF- alpha inhibitory activity. The formulations also may include one or more of the following herbs which, according to the invention, inhibit PGE2: Hou Po Magnoliae officinalis, Huang Bai Phellodendron chinense, Huang Lian Coptis chinensis, Huo Xiang Agastaches rugosa, Pao Jiang Zingiberis officinalis, Qin Pi Fraxinus rynchophylla, and Zhi Gan Cao Glycyrhizae inflata. Cette invention se rapporte à des compositions, y compris des formulations, de plantes pour le traitement des maladies intestinales inflammatoires, du syndrome du côlon irritable et des états inflammatoires et autres états apparentés, tels que l'arthrite. Ces formulations contiennent l'une et/ou l'autre des deux herbes Chen Pi (Citrus reticulata) et Wu Mei (Prunus mume), qui, selon cette invention, possèdent une action inhibitrice importante du facteur TNF- alpha à base de cytokines. Ces formulations peuvent également contenir une ou plusieurs des herbes suivantes qui, selon cette invention, inhibent la prostaglandine E2 (PGE)2: Hou Po (Magnoliae officinalis), Huang Bai (Phellodendron chinense), Huang Lian (Coptis chinensis), Huo Xiang (Agastaches rugosa), Pao Jiang (Zingiberis officinalis), Qin Pin (Fraxinus rynchophylla), et Zhi Gan Cao (Glycyrhizae inflata).