ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND MATERIALS FOR THEIR SYNTHESIS

Compounds of formula (I), where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of formula (II) where the formula variables are as defined herein that advantageously...

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Bibliographic Details
Main Authors ZHOU, RU, DRAGOVICH, PETER, S, JOHNSON, THEODORE, O., JR, PRINS, THOMAS, J
Format Patent
LanguageEnglish
French
Published 07.06.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I), where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of formula (II) where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described. Cette invention concerne des composés représentés par la formule (I) dont les variables sont telles que définies dans le descriptif de l'invention. Ces composés offrent l'avantage d'inhiber ou de bloquer l'activité biologique de la protéase 3C picornavirale. En outre, cette invention concerne des composés représentés par la formule (II), dont les variables sont telles que définies dans le descriptif de l'invention. Ces composés offrent l'avantage d'inhiber ou de bloquer l'activité biologique de la protéase 3C picornavirale. Ces composés, ainsi que les compositions pharmaceutiques qui les renferment, conviennent pour le traitement de patients ou d'hôtes infectés par un ou plusieurs picornavirus, tels que des protéases 3C à rhinovirus. Sont également décrit des produits intermédiaires ainsi que des méthodes synthétiques de fabrication de tels composés.
Bibliography:Application Number: WO2000US32621