PROTEINS AND POLYNUCLEOTIDES ENCODED THEREBY

• Main Authors: LICHENSTEIN, HENRI, SHIMKETS, RICHARD, A, BOLDOG, FERENC, L
• Format: Patent
• Language: English; French
• Published: 18.04.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention provides novel polypeptides, termed MBSPX polypeptides, as well as polynucleotides encoding MBSPX polypeptides and antibodies that immunospecifically bind to an MBSPX or a derivative, variant, mutant, or fragment of an MBSPX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the MBSPX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses. L'invention concerne de nouveaux peptides, appelés polypeptides MBSPX, ainsi que des polynucléotides codant des polypeptides et des anticorps MBSPX qui se lient de manière immunospécifique à un MBSPX ou à un dérivé, variant, mutant ou fragment d'un polypeptide, d'un polynucléotide ou d'un anticorps MBSPX. L'invention concerne en outre des méthodes dans lesquelles le polypeptide, le polynucléotide et l'anticorps MBSPX sont utilisés pour la détection et le traitement d'un large éventail d'états pathologiques, ainsi que pour d'autres usages.