PHOSPHONIC ACID DERIVATIVES HAVING CARBOXYPEPTIDASE B INHIBITORY ACTIVITY
Compounds represented by general formula (I), wherein R represents hydrogen, alkyl, substituted alkyl, etc.; R and R each represents hydrogen, alkyl, substituted alkyl, alkoxy, etc.; X represents -CH2-, -O-, or -NH-; A represents a group represented by formula (II)(wherein R and R each represents hy...
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Main Authors | , , , , , , |
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Format | Patent |
Language | English French Japanese |
Published |
22.03.2001
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Compounds represented by general formula (I), wherein R represents hydrogen, alkyl, substituted alkyl, etc.; R and R each represents hydrogen, alkyl, substituted alkyl, alkoxy, etc.; X represents -CH2-, -O-, or -NH-; A represents a group represented by formula (II)(wherein R and R each represents hydrogen, alkyl, acyl, alkoxycarbonyl, etc.; and R and R each represents hydrogen, halogeno, hydroxy, phenyl, alkyl, etc.), etc.; and E represents hydrogen, etc., or pharmacologically acceptable salts thereof. These compounds have carboxypeptidase B inhibitory activity and are useful for the treatment and/or prevention of thrombotic diseases.
L'invention concerne des composés de formule générale (I) [dans laquelle R représente un hydrogène, alkyle, alkyle substitué, etc.; R et R représentent chacun un hydrogène, alkyle, alkyle substitué, alcoxy, etc.; X représente -CH2-, -O-, ou -NH-; A représente un groupe de formule (II) (dans laquelle R et R représentent chacun un hydrogène, alkyle, acyle, alcoxycarbonyle, etc.; et R et R représentent chacun un hydrogène, halogène, hydroxy, phényle, alkyle, etc.), etc.; et E représente un hydrogène, etc.]. L'invention concerne également leurs sels acceptables sur le plan pharmaceutique. Ces composés présentent une activité inhibitrice de carboxypeptidase B et sont utiles dans le traitement et/ou la prévention d'affections thrombotiques. |
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Bibliography: | Application Number: WO2000JP06248 |