HCV/BVDV CHIMERIC GENOMES AND USES THEREOF

• Main Authors: EMERSON, SUZANNE, U, BUKH, JENS, PURCELL, ROBERT, H, NAM, JAE-HWAN
• Format: Patent
• Language: English; French
• Published: 15.11.2001
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV-BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV. L'invention concerne des approches moléculaires de la production de séquences d'acide nucléique contenant les génomes recombinants des virus de l'hépatite C/virus de la diarrhée virale bovine (VHC-BVDV). L'invention concerne également l'utilisation de ces séquences recombinantes d'acide nucléique pour produire des virions recombinants dans des cellules, et l'utilisation de ces virions recombinants dans des méthodes de neutralisation d'anticorps de VHC, et pour la mise au point de vaccins et de traitements dirigés contre le VHC.