IMPLANTABLE GEL COMPOSITIONS AND METHOD OF MANUFACTURE

Methods and compositions for reducing the burst of beneficial agent from implantable systems is described. Such systems utilize compressed particulates of a beneficial agent, optionally mixed with a dissolution rate modulator or an agent exhibiting a characteristic of low solubility in water, such a...

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Bibliographic Details
Main Authors BRODBECK, KEVIN, J, PUSHPALA, SHAMIM, J, PRESTRELSKI, STEVEN, J
Format Patent
LanguageEnglish
French
Published 05.07.2001
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods and compositions for reducing the burst of beneficial agent from implantable systems is described. Such systems utilize compressed particulates of a beneficial agent, optionally mixed with a dissolution rate modulator or an agent exhibiting a characteristic of low solubility in water, such as a mixture of stearic acid and palmitic acid, dispersed throughout a bioerodible and biocompatible carrier. L'invention concerne des méthodes et des compositions servant à réduire l'éclatement d'un agent bénéfique dans des systèmes implantables. Ces systèmes comprennent des particules comprimées d'un agent bénéfique, éventuellement mélangées avec un modulateur de débit de dissolution ou un agent présentant une caractéristique de faible solubilité dans l'eau, par exemple un mélange d'acide stéarique et d'acide palmitique, dispersé dans un porteur bioérodable et biocompatible.
Bibliography:Application Number: WO2000US15383