IDENTIFICATION OF CANDIDA ALBICANS ESSENTIAL FUNGAL SPECIFIC GENES AND USE THEREOF IN ANTIFUNGAL DRUG DISCOVERY

• Main Authors: DAVISON, JOHN, BUSSEY, HOWARD, ROEMER, TERRY
• Format: Patent
• Language: English; French
• Published: 16.11.2000
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to the identification and disruption of essential fungal specific genes isolated in the yeast pathogen Candida albicans namely CaKRE5, CaALR1 and CaCDC24 and to the use thereof in antifungal diagnosis and as essential antifungal targets in a fungal species for antifungal drug discovery. More specifically, the invention relates to the CaKRE5, CaALR1 and CaCDC24 genes, to their use to screen for antifungal compounds and to the drugs identified by such. L'invention concerne l'identification et le dysfonctionnement de gènes spécifiques fongiques essentiels isolés dans les Candida albicans pathogènes de levure, à savoir CaKRE5, CaALR1 et CaCDC24, et leur utilisation dans le diagnostic antifongique et en tant que cibles antifongiques essentielles dans une espèce fongique destinée à la découverte de médicaments antifongiques. Plus particulièrement, cette invention concerne les gènes CaKRE5, CaALR1 et CaCDC24, leur utilisation dans le dépistage de composés antifongiques, et les médicaments ainsi identifiés.