POLLINOSIS-ASSOCIATED GENE 373

• Main Authors: OSHIDA, TADAHIRO, OGAWA, KAORU, MATSUI, KEIKO, OBAYASHI, MASAYA, GUNJI, SHIGEMICHI, SUGITA, YUJI, KASHIWABARA, TOMOKO, IMAI, YUKIHO, OBAYASHI, IZUMI, YOSHIDA, NEI, NAGASU, TAKESHI
• Format: Patent
• Language: English; French; Japanese
• Published: 02.11.2000
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

A novel gene undergoing significantly low expression in subjects showing high cedar pollen-specific IgE levels. This gene has been successfully isolated by preparing T cells from subjects showing different cedar pollen-specific IgE levels before and after the pollen-scattering season and searching the gene by the differential display method. It is found out that this gene is usable in examining allergic diseases and screening candidate compounds for remedies for allergic diseases. L'invention concerne un nouveau gène, caractérisé par un niveau d'expression particulièrement faible chez les sujets présentant des taux élevés d'IgE spécifique au pollen de cèdre, et que l'on a réussi à isoler par la préparation de lymphocytes T à partir de sujets présentant différents taux d'IgE spécifique au pollen de cèdre avant et après la saison des pollens, et par la recherche dudit gène selon la technique de l'affichage différentiel. On a découvert que ce gène pouvait être utilisé dans l'examen des allergies et le criblage de composés candidats pour des remèdes contre les allergies.