FLINT POLYPEPTIDE ANALOGS

• Main Authors: MICANOVIC, RADMILA, RATHMACHALAM, RADHAKRISHNAN, COHEN, FREDRIC, JAY, HALE, JOHN, EDWARD, TSCHANG, SHENG-HUNG, RAINBOW, NOBLITT, TIMOTHY, WAYNE, WROBLEWSKI, VICTOR, JOHN, BECKER, GERALD, WAYNE, NEWTON, CHRISTY, MICHELLE, GONZALEZ-DEWHITT, PATRICIA, ANN, WITCHER, DERRICK, RYAN
• Format: Patent
• Language: English; French
• Published: 25.01.2001
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed are polypeptide analogs of FLINT, polydeoxynucleotides encoding FLINT analogs, and methods of using FLINT analogs and polydeoxynucleotides. The FLINT analogs of the invention include polypeptides having the amino acid sequence of FLINT, modified at one or more positions with amino acid substitutions, and include fragments thereof, as well as Fc fusions comprising FLINT and FLINT analogs. L'invention concerne des analogues polypeptidiques de FLINT (FAS Ligand Inhibitory proteins/protéines inhibitrices de ligands FAS), des polydésoxynucléotides codant pour les analogues de FLINT et des méthodes d'utilisation de polydésoxynucléotides et d'analogues de FLINT. Les analogues de FLINT de l'invention comprennent des polypeptides possédant la séquence d'acides aminés de FLINT, modifiée au niveau d'une ou plusieurs positions par des substitutions d'acide aminé, et comprennent des fragments de celles-ci, ainsi que des fusions Fc comprenant FLINT et des analogues de FLINT.