TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES

Compounds of formula (I) are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in...

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Main Authors TIKHE, JAYASHREE, WEBBER, STEPHEN, EVAN, THORESEN, LARS, HENRIK, CANAN-KOCH, STACIE, S
Format Patent
LanguageEnglish
French
Published 20.07.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I) are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation. Cette invention concerne des composés représentés par la formule (I) ci-dessous qui sont des inhibiteurs de la poly(ADP-ribosyl)transferase (PARP) et qui sont utiles pour le traitement des cancers et atténuent les effets d'attaques, de traumatismes crâniens et des maladies neurodégénératives. En tant qu'agents thérapeutiques des cancers, les composés selon l'invention peuvent s'employer notamment en combinaison avec des agents cytotoxiques et/ou des rayons.
Bibliography:Application Number: WO2000US00411