MEGAKARYOCYTE-INDUCED EXPANSION OF HEMATOPOIETIC STEM CELLS

The invention relates to hematopoietic stem cell (HSC) compositions comprising HSC, megakaryocytes, stromal cells and culture conditions effective to result in at least a five-fold increase in cells having the phenotype and function of HSC after one month in culture and methods for obtaining the sam...

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Main Authors YAGI, MAYUMI, BARTELMEZ, STEPHEN, H, RITCHIE, KINDRED, A, SITNICKA, EWA, STOREY, CARL, ROTH, GERALD, J
Format Patent
LanguageEnglish
French
Published 15.06.2000
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to hematopoietic stem cell (HSC) compositions comprising HSC, megakaryocytes, stromal cells and culture conditions effective to result in at least a five-fold increase in cells having the phenotype and function of HSC after one month in culture and methods for obtaining the same. Cette invention concerne des compositions à base de cellules souches hématopoïétiques (HSC) comprenant des HSC, des mégacaryocytes et des cellules du stroma. L'invention concerne également des conditions de culture permettant de multiplier par au moins cinq le nombre de cellules présentant le phénotype et la fonction de HSC après un mois de culture ainsi que des méthodes permettant d'atteindre ce résultat.
Bibliography:Application Number: WO1999US29138