CRYSTALLIZABLE FARNESYL PROTEIN TRANSFERASE COMPOSITIONS, CRYSTALS THEREBY OBTAINED AND METHODS FOR USE

The present invention relates to crystalline compositions comprising farnesyl protein transferase-like polypeptides in complex with substrates and inhibitors. Also disclosed are crystallization conditions for these compositions and their use for structural determination of FPT:FPP/FPP analog: peptid...

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Bibliographic Details
Main Authors WINDSOR, WILLIAM, T, STRICKLAND, COREY, WU, ZHEN, WEBER, PATRICIA, C
Format Patent
LanguageEnglish
French
Published 10.02.2000
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to crystalline compositions comprising farnesyl protein transferase-like polypeptides in complex with substrates and inhibitors. Also disclosed are crystallization conditions for these compositions and their use for structural determination of FPT:FPP/FPP analog: peptide/inhibitor complexes. L'invention concerne des compositions cristallines comprenant des polypeptides du type farnésyl-transférase, formant un complexe avec des substrats et des inhibiteurs. L'invention concerne également des conditions de cristallisation de ces compositions ainsi que l'utilisation de celles-ci dans la détermination structurelle de complexes formés par le polypeptide de type farnésyl-transférase(FPT) avec la farnésyl-diphosphate (FPP) ou avec un analogue de la farnésyl-diphosphate (FPP) et avec un peptide ou un inhibiteur.
Bibliography:Application Number: WO1999US16684