ANTICUERPOS CONTRA EL RECEPTOR BETA DE ONCOSTATINA M CANINO Y FELINO Y SUS USOS

• Main Authors: Andrea Joy GONZALES, Gary Francis BAMMERT
• Format: Patent
• Language: Spanish
• Published: 30.06.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

La invención proporciona un anticuerpo aislado, o una porción de unión a antígeno de él que se une específicamente al receptor Beta de Oncostatina M canino o felino (OSMR-ß) o a ambos, en donde el anticuerpo antagoniza la señalización mediada por IL-31 o la señalización mediada por OSM o ambas en una célula canina y/o felina. The invention provides an isolated antibody, or antigen-binding portion thereof that specifically binds to canine or feline Oncostatin M receptor Beta (OSMR-β) or both, wherein the antibody antagonizes IL-31-mediated signaling or OSM-mediated signaling or both in a canine and/or feline cell.